Shanghai Precision Diagnostics and Fudan University Shanghai Cancer Center Launch Breast Cancer Biomarker Study Using 10x Genomics' Xenium Platform

Study aims to identify biomarkers that could predict how patients with breast cancer respond to neoadjuvant therapy

PLEASANTON, Calif., Nov. 10, 2026 /PRNewswire/ -- 10x Genomics, Inc. (Nasdaq: TXG), the life science technology leader focused on accelerating science and advancing human health, today announced that Fudan University Shanghai Cancer Center (FUSCC) and Shanghai Precision Diagnostics Co. Ltd (SPDx), will deploy its Xenium platform in a 24-month study. The project seeks to identify biomarkers that may predict how patients with breast cancer respond to neoadjuvant therapy, or treatment administered before surgery to shrink tumors. FUSCC and SPDx intend to use the findings from the study to inform their development of potential future diagnostic approaches.

This study plans to analyze pretreatment tumor biopsy samples from 500 patients receiving neoadjuvant therapy. Researchers will use the Xenium platform, with the potential for future expansion to the Atera platform, to profile tumor gene expression of each tumor and compare those findings with treatment outcomes to identify cellular features and pathways associated with treatment response and resistance.

"Patients with breast cancer can respond very differently to the same treatment, and we still lack reliable tools to predict those differences," said Zhimin Shao, Director of the Breast Cancer Center at FUSCC. "We hope this study will identify biological characteristics of tumors before treatment that will allow us to predict outcomes. Such discoveries could someday also guide personalized treatment decisions and create new opportunities to improve therapeutic efficacy and patient prognosis."

"By combining FUSCC's clinical expertise with the cellular-resolution view of tumors provided by Xenium, we hope to uncover biomarkers that conventional methods may overlook and ultimately support more precise treatment decisions for patients with breast cancer," said Tong Zhou, CEO of SPDx.

Earlier this year, 10x outlined its clinical strategy with two complementary paths for realizing the potential of single cell and spatial technologies in diagnostics. One path is to enable customers to use 10x technologies in translational research that may inform the development of their own potential diagnostic approaches. The other is for 10x to directly advance selected diagnostic applications by generating the evidence that could support their future clinical use. The FUSCC and SPDx study exemplifies the customer-driven path and complements academic collaborations in oncology that 10x announced earlier in the year.

"Biology is incredibly complex, and many of today's diagnostic approaches capture only a limited view of the cellular interactions and spatial context that may influence treatment response. Single cell and spatial technologies have the potential to enable a new generation of diagnostics informed by deeper insights into disease biology," said Roman Yelensky, Vice President, Clinical Applications at 10x Genomics. "FUSCC and SPDx are pursuing exactly the kind of ambitious research needed to make that future possible. Their work can move us closer to a world where clinicians have greater clarity about which treatments are most likely to work, transforming cancer care."

About 10x Genomics

10x Genomics is a life science technology company building products to accelerate the mastery of biology and advance human health. Our integrated research solutions include instruments, consumables and software for single cell and spatial biology, which help academic and translational researchers and biopharmaceutical companies understand biological systems at a resolution and scale that matches the complexity of biology. Our products are behind breakthroughs in oncology, immunology, neuroscience and more, fueling powerful discoveries that are transforming the world's understanding of health and disease. To learn more, visit 10xgenomics.com or connect with us on LinkedIn, X, Facebook, Bluesky or YouTube.

About Fudan University Shanghai Cancer Center (FUSCC) 

Fudan University Shanghai Cancer Center (FUSCC) is directly affiliated with Fudan University. It is a budgetary institution under China's National Health Commission. Founded in 1931, FUSCC is China's first specialist cancer hospital. It is also Shanghai's top cancer hospital, integrating clinical care, education, research, and prevention. The Department of Breast Surgery was established in 2000. With 277 beds across five inpatient wards and more than 10,000 breast cancer surgeries performed annually, it is one of the largest breast centers worldwide. The department is designated as a National Key Clinical Specialty. It also houses the Shanghai Clinical Medical Center for Breast Cancer and the Shanghai Key Laboratory of Breast Cancer.

About Shanghai Precision Diagnostics Co. Ltd (SPDx)

Shanghai Precision Diagnostics Co. Ltd. (SPDx) is a precision medicine biotech company focused on molecular diagnostics, spatial biology and multi-omics technologies. Headquartered at the South Shanghai Science and Technology Innovation Center in China, with an R&D center in Research Triangle Park, North Carolina, USA, SPDx is dedicated to advancing precision oncology through technological innovation and clinical translation. The company has built three fully integrated technology platforms: mRNA expression-based tumor molecular subtyping, in situ single-cell spatial transcriptomics, and AI-powered multi-omics analysis. Backed by its state-of-the-art clinical laboratory and deep expertise in molecular diagnostics, SPDx delivers innovative solutions for tumor molecular classification, biomarker discovery, treatment response prediction and personalized medicine.

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